中国猪繁殖与呼吸综合征病毒流行历史及现状

doi:10.11843/j.issn.0366-6964.2018.01.001

摘要/Abstract

摘要：

猪繁殖与呼吸综合征是当今世界危害养猪业的非常重要的疫病之一。我国自1995年首次报道本病以来，至今已流行20余年。本文从分子流行病学的角度系统分析我国猪繁殖与呼吸综合征病毒（porcine reproductive and respiratory syndrome virus，PRRSV）的流行历史及现状，希望为PRRSV的防控提供新的视角和参考。当前美洲型（genotype 2）和欧洲型（genotype 1）PRRSV在我国均有流行，基于ORF5基因的序列分析显示，我国美洲型流行毒株分属于lineage 8、lineage 5、lineage 3和lineage 1四个谱系，且当前以lineage 8（highly pathogenic PRRSV-like）和lineage 1（NADC30-like）为主。我国早期毒株BJ-4与VR2332的全基因组相似性为99.6%，提示BJ-4可能为北美输入性毒株。我国欧洲型毒株均属于subtype 1，目前至少有9个省市检测到了欧洲型毒株的流行，与Lelystad virus毒株相比，我国流行毒株的GP5和N蛋白上均具有特有的保守氨基酸位点。

Abstract:

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases in the world. It has been more than twenty years since the first report in China. The objective of this paper is to analyse the prevalent history and current status through a perspective of epidemiology, aiding to the prevention of PRRS virus (PRRSV). Both genotype 1 and genotype 2 PRRSV are prevalent in China. For genotype 2, majority of epidemic strains in the fields were clustered into four lineages (lineage 8, lineage 5, lineage 3 and lineage 1), among which lineage 8 (highly pathogenic PRRSV-like) and lineage 1 (NADC30-like) are dominant viruses. The genome homology between BJ-4 and VR2332 is 99.6%, which suggested that BJ-4 was probably imported from North America region. For genotype 1, all the isolated strains in China belong to subtype 1 and were detected in more than 9 provinces/regions. The Chinese isolated strains have highly conserved amino acid mutation sites on the GP5 and N protein compared with Lelystad virus.

中图分类号:

S858.285.3

郭振华, 陈鑫鑫, 李睿, 乔松林, 郭军庆, 张改平. 中国猪繁殖与呼吸综合征病毒流行历史及现状[J]. 畜牧兽医学报, 2018, 49(1): 1-9.

GUO Zhen-hua, CHEN Xin-xin, LI Rui, QIAO Song-lin, GUO Jun-qing, ZHANG Gai-ping. The Prevalent History and Current Status of Porcine Reproductive and Respiratory Syndrome in China[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(1): 1-9.

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